For many cat owners, cleaning the litter box is the most dreaded chore. Between scooping waste, controlling odors, and dealing with dust, it can feel like a never-ending battle. That’s why more people are turning to automatic litter boxes—a hands-free solution that keeps things cleaner and easier.
At the same time, Pretty Litter has become one of the most popular choices among cat parents. Known for its color-changing crystals that help monitor feline health, it’s also lightweight, long-lasting, and marketed as a low dust cat litter. The challenge? Finding an automatic litter box that works with Pretty Litter without clogging, overfilling, or losing its health-tracking benefits.
If you’re also interested in other styles like stainless steel, top-entry, or furniture-style litter boxes, make sure to check out our Best Cat Litter Boxes in 2025 guide for more options.
In this guide, we’ve done the research for you. We’ll compare six of the top-rated self-cleaning litter boxes from Amazon and Chewy, explain how they perform with Pretty Litter, and give you practical tips for getting the best results. By the end, you’ll know exactly which option suits your cat’s needs—and your lifestyle.
Why Pair Pretty Litter With an Automatic Litter Box?
If you already use Pretty Litter, you know it’s more than just cat litter—it’s a tool for keeping your cat healthy and your home fresh. But when you combine this unique formula with an automatic litter box, the benefits multiply, making daily cat care easier and cleaner.
1. Convenience and Time-Saving
Scooping every day can be frustrating, especially for busy pet parents. Automatic litter boxes do the dirty work for you, raking or cycling waste away while you focus on more important things. When paired with Pretty Litter, you still get the same health-monitoring crystals without the constant hassle of cleaning.
2. Cleaner, Low-Dust Experience
Pretty Litter is designed as a low dust cat litter, which means less mess around your home and fewer irritants in the air. Self-cleaning boxes enhance this by keeping litter contained and reducing the need to stir or pour as often—both of which can release extra dust.
3. Ongoing Health Monitoring
One of Pretty Litter’s standout features is how its crystals change color to indicate potential health issues. An automatic litter box doesn’t interfere with this; instead, it provides a cleaner surface that makes the color changes easier to spot. Whether your cat has urinary concerns or digestive sensitivities, you’ll be able to see the signals clearly.
4. Better Odor Control
Crystal-based formulas like Pretty Litter are excellent at absorbing moisture and locking in odors. An automatic litter box complements this by regularly removing waste, preventing smells from building up over time.
In short, Pretty Litter already stands out as a crystal litter for cats that promotes both hygiene and health. Paired with an automatic litter box, it transforms from a great product into a complete, low-maintenance system that saves you time, keeps your home fresher, and helps protect your cat’s well-being.
Top Automatic Litter Boxes That Work With Pretty Litter
Finding the right automatic litter box that works with Pretty Litter can be tricky. Below are six of the most popular and best-reviewed options from Amazon and Chewy, compared for compatibility, features, and real user feedback.

Whisker Litter-Robot 4
Why it’s popular: The Litter-Robot 4 is considered the gold standard of self-cleaning litter boxes. It uses a rotating globe to separate waste from clean litter, and many cat owners praise its smart app features, excellent odor control, and low-dust performance.

- Pros: Large capacity, tracks cat usage and weight, strong odor control, health insights via the app.
- Cons: Expensive; requires space; learning curve for first-time users.
- Relevance: The most asked question is, “Does Litter-Robot 4 work with Pretty Litter?” Many owners successfully use silica crystals, though some recommend adjusting fill levels to optimize cycling.

PetSafe ScoopFree Crystal Pro
Why it’s popular: The PetSafe ScoopFree Crystal Pro is a budget-friendly automatic litter box that uses a rake system with disposable trays pre-filled with silica crystals. It’s simple, low-maintenance, and already designed for crystal litter.

- Pros: Affordable; easy setup; low-maintenance trays; naturally compatible with crystal litter.
- Cons: Replacement tray costs add up; rake may need occasional cleaning.
- Relevance: Ideal for cat owners who want a straightforward option for Pretty Litter compatibility without spending premium prices.

Casa Leo Leo’s Loo Too
Why it’s popular: Known for its sleek, modern design and quiet motor, the Leo’s Loo Too is another strong contender. It automatically separates waste and connects to a mobile app for real-time updates.

- Pros: Whisper-quiet operation; attractive design; app integration with smart alerts.
- Cons: More expensive than PetSafe; cleaning takes longer due to design complexity.
- Relevance: A mid-to-high tier option that balances design, convenience, and Pretty Litter compatibility, making it popular among multi-cat households.

Neakasa M1
Why it’s popular: The Neakasa M1 has gained attention for being spacious enough for larger cats while staying affordable compared to premium models.

- Pros: Large interior for bigger cats; accessible price point; decent automation.
- Cons: Reliability issues reported in some reviews; not as feature-rich as Litter-Robot.
- Relevance: A solid mid-range choice for budget-conscious pet parents experimenting with Pretty Litter.

Catlink Luxury Pro-X Automatic Self-Cleaning Litter Box
Why it’s popular: The Catlink ProX series combines stylish design with app controls and customizable features. Many users like its dust control and modern look.

- Pros: Smart app; customizable cleaning schedules; sleek appearance.
- Cons: Durability concerns in long-term use; higher maintenance compared to simpler models.
- Relevance: Appeals to tech-savvy cat owners who want a smart, stylish litter box that can work with Pretty Litter crystals.

Petkit Purobot Ultra
Why it’s popular: The Petkit Purobot Ultra is one of the most advanced self-cleaning litter boxes available. It uses AI-powered sensors, facial recognition, and a 4-stage odor control system to keep your cat’s space clean and fresh. With app integration and touch-free waste disposal, it’s built for maximum convenience.

- Pros: AI-powered health and usage tracking; excellent odor control; app integration with Wi-Fi; modern, stylish design.
- Cons: Heavy (46 lbs); expensive; parts are more complex to maintain; availability can be limited.
- Relevance: A high-end automatic litter box that works with Pretty Litter, offering cutting-edge features for cat owners who want the latest in pet tech.
How to Use Pretty Litter in an Automatic Litter Box
Using Pretty Litter in an automatic litter box can make life much easier, but it works best when you follow a few simple adjustments. Because Pretty Litter is a crystal litter for cats, it behaves differently from traditional clumping clay. Here’s how to get the most out of it:
1. Fill to the Right Level
Avoid overfilling the box. Most self-cleaning systems perform better with a shallower layer of litter. Stick to the recommended depth (usually 2–3 inches) so the sensors and rake mechanism can work without issues.
2. Adjust Cleaning Cycles
Automatic boxes often allow you to set the delay between when your cat leaves and when the cleaning cycle begins. A slightly longer delay gives Pretty Litter crystals time to absorb moisture, reducing clumps that may stick or break apart during raking.
3. Keep Dust Low
Pretty Litter is already a low dust cat litter, but pouring it too quickly can create unnecessary particles. Pour slowly, and try to add fresh litter in smaller amounts during refills. This keeps the environment cleaner for both you and your cat.
4. Watch for Color Changes
Pretty Litter’s biggest advantage is its color-changing health indicator. Automatic boxes make it easier to see fresh litter after each cycle, so check the crystals regularly. If you notice unusual colors, it may be time for a vet visit.
5. Replace on Schedule
Even with an automatic litter box, Pretty Litter needs replacing about once a month for a single cat. For multi-cat households, replace more often to keep the health indicators accurate and maintain odor control.
Buyer’s Guide – Choosing the Right Automatic Litter Box
Not every automatic litter box that works with Pretty Litter will be the best fit for your cat or your home. Before buying, consider these important factors to make sure you get the right balance of performance, convenience, and cost.
Size & Design
If you have a large cat or more than one cat, make sure the litter box has enough room for comfort. Spacious models like the Litter-Robot 4 or Neakasa M1 are better suited for big breeds, while compact designs like the PetSafe ScoopFree Crystal Pro work well for smaller spaces or single-cat households. Think about where you’ll place it—quiet corners are best.
For other litter box designs, such as stainless steel pans, top-entry styles, or furniture-style enclosures, you can explore our Best Cat Litter Boxes in 2025 guide to find more options beyond self-cleaning models.
Waste System
Self-cleaning boxes use different methods: rotating globes, raking trays, or sifting systems. Crystal-based formulas like Pretty Litter perform best in boxes that allow moisture to be absorbed fully before the waste is cleared. A slightly longer cycle delay can make a big difference in performance and keep the crystal litter for cats working effectively.
Odor & Dust Control
Pretty Litter is already a low dust cat litter, which helps keep your air clean and reduces allergens. However, odor control depends on the litter box design. Models with sealed waste drawers (like Casa Leo or Catlink ProX) lock in smells better than open trays. If odor is a top concern, look for units with carbon filters or enclosed disposal bins.
Ongoing Costs
Some units require disposable trays, cartridges, or frequent filter replacements. While budget models may seem cheaper upfront, replacement supplies can add up over time. Premium models like Litter-Robot cost more initially but may save money in the long run. Balance your budget with your willingness to manage ongoing maintenance.
By weighing these four factors, you can choose a self-cleaning litter box that not only works with Pretty Litter but also fits your cat’s size, your home’s layout, and your budget.
FAQs About Pretty Litter & Automatic Litter Boxes
Does Pretty Litter work in an automatic litter box?
Yes, Pretty Litter can be used in many automatic litter boxes. Since it’s a crystal litter for cats, it doesn’t clump like clay but instead absorbs moisture. To get the best results, keep the litter depth around 2–3 inches and allow enough delay time for the crystals to absorb before the box cycles.
What do Pretty Litter colors mean?
- One of Pretty Litter’s most unique features is its color-changing formula.
- Yellow/Olive – Normal urine.
- Blue – Possible high urinary pH, which could mean a urinary tract infection.
- Red – May signal blood in the urine.
- Orange – Could indicate acidity, sometimes linked to metabolic issues. Monitoring these Pretty Litter colors helps cat owners detect potential health issues early.
Is Pretty Litter safe for cats?
Yes, Pretty Litter is generally considered safe. It’s made of silica gel crystals, which are non-toxic and commonly used in pet litters. The product is designed to minimize dust and reduce tracking, making it safer for both cats and humans with allergies. However, as with any litter, make sure your cat does not ingest it.
Is Pretty Litter really a low dust cat litter?
Yes. Pretty Litter is marketed as a low dust cat litter, which makes it especially useful for households with asthma, allergies, or dust-sensitive cats. Pouring slowly and keeping the box in a well-ventilated area further reduces airborne particles.
How often should you change Pretty Litter in an automatic litter box?
For a single cat, Pretty Litter should be replaced about once a month. In multi-cat households, replacing every 2–3 weeks works better. Even though an automatic litter box removes waste regularly, the crystals eventually lose their ability to absorb and control odor, so staying on schedule is important.
Is Pretty Litter worth it?
Many cat owners say yes. While it may cost more than traditional litter, it offers unique benefits: health monitoring through color changes, strong odor control, and reduced dust. When paired with the convenience of an automatic litter box, it saves time and provides peace of mind about your cat’s health.
Conclusion
Pairing Pretty Litter with the right automatic litter box that works with Pretty Litter gives cat owners the perfect balance of convenience, cleanliness, and health monitoring. You’ll spend less time scooping, enjoy a fresher home, and gain peace of mind knowing the litter can alert you to potential health concerns.
Whether you choose a premium model like the Litter-Robot 4, a mid-range option such as Leo’s Loo Too, or a budget-friendly pick like the PetSafe ScoopFree Crystal Pro, each offers unique advantages to suit your lifestyle and budget.
Now is the time to make cat care easier. Explore the top automatic litter boxes we’ve reviewed and find the one that keeps both you and your cat happy.